سه‌شنبه ۱۲ آذر ۱۳۸۷ ه‍.ش.

فارماکوکینتیک Pharmacokinetics


برای آشنایی با مفاهیم فارماکوکینتیک مانند فراهمی زیستی،کلیرانس دارو،متابولیسم دارو، اثر عبور اوّل، کینتیک درجه اول و درجه صفر و مفاهیمی مانند فارماکودینامیک و فارماکوژنتیک از این سایت که به صورت انیمیشن می باشد استفاده کنید:
Interactive Clinical Pharmacology

Drug Clearance
The most important pharmacokinetic parameter. Determines maintenance dose. Saturable Metabolism
When drug concentrations exceed the capacity of metabolism.


Drug Elimination
About renal clearance and hepatic metabolism. Protein Binding
Only important in interpreting
measured drug concentrations.


Volume of Distribution
The volume into which a drug appears to be distributed. Determines loading dose. pH and Pharmacokinetics
Acids are ionized in basic media.
Bases are ionized in acidic media.


Half Life
The time for the concentration of
the drug to halve. Dosing and Age
Drug clearance and dose
requirements vary markedly throughout life.


Dosing-I.V. vs oral vs slow release
The route of drug administration influences pharmacokinetics. Drugs in Pregnancy
Effect of drugs on the pregnancy.
Effect of pregnancy on the drugs.


Oral Availability
The fraction of drug that reaches the
systemic circulation after oral ingestion. Drug Interactions
How one drug affects the concentrations or actions of another.


Pharmacodynamics
The action of the drug on the body. Drug Transport
Active transporters can help prevent some drug toxicities and aid uptake of some drugs.

Pharmacogenetics
How genes determine drug concentrations

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