۱۳۸۷ بهمن ۱۲, شنبه

Analysis of Genes and Genomes

Analysis of Genes and Genomes is a clear introduction to the theoretical and practical basis of genetic engineering, gene cloning and molecular biology. All aspects of genetic engineering in the post-genomic era are covered, beginning with the basics of DNA structure and DNA metabolism. Using an example-driven approach, the fundamentals of creating mutations in DNA, cloning in bacteria, yeast, plants and animals are all clearly presented.
Newer technologies such as DNA macro and macroarrays, proteomics and bioinformatics are introduced in later chapters helping students to analyse and understand the vast amounts of data that are now available through genome sequence and function projects.
Aimed at students with a basic knowledge of the molecular side of biology, this will be invaluable to those looking to better understand the complexities and capabilities of these important new technologies.
A modern post-genome era introduction to key techniques used in genetic engineering.
An example driven past-to-present approach to allow the experiments of today to be placed in an historical context
Beautifully illustrated in full colour throughout.
Associated website including updates, additional content and illustrations

۱۳۸۷ بهمن ۱۱, جمعه

Flavonoids in Health and Disease, Second Edition

Revised and expanded, this blue-ribbon reference emphasizes the latest developments in the identification, utilization, and analysis of flavonoids for the prevention of disease and maintenance of good health. The book examines the processes involved in the absorption, metabolism, distribution, and excretion of these compounds and the impact of biotransformation on flavonoid function. The Second Edition contains new discussions on the potential of dietary flavonoids to attenuate neurological dysfunction and degeneration, developments in gene expression and genomics for identification of therapeutic targets and markers of disease, and the mechanisms regulating flavonoid bioavailability.

Guide to Antimicrobial Use in Animals

The first book to offer practical guidelines on the prudent and rational use of antimicrobials in animals. Drawing on multidisciplinary expertise to offer independent scientific advice on a controversial area that is crucial to both human health and animal welfare. The earlier general chapters cover issues such as human health risks and the problems of resistance to antimicrobial drugs. The later specific chapters are dedicated to particular groups of animals.* Has an emphasis on preserving the efficacy of antimicrobial drugs that are clinically important in human medicine* Covers both companion animals and food animals, including aquaculture* Suitable for veterinary practitioners working in small and large animal medicine, aquaculture and animal production, as well as veterinary students, academics and researchers. It will also be of interest to those more generally involved in veterinary public health and antimicrobial resistance.

۱۳۸۷ بهمن ۸, سه‌شنبه

Local Drug Delivery for Coronary Artery Disease

Restenosis remains the Achilles heel of Percutaneous Coronary Interventions. Numerous pharmacological agents have been tested in order to reduce acute thrombosis and the hyperproliferative cellular response, and drug eluting stents-using the stent as a platform for local drug delivery-are now considered a significant breakthrough in interventional cardiology. Pioneers in the field, the editors of Local Drug Delivery for Coronary Artery Disease have assembled an excellent team of contributors who offer their experience with threatened vessel closure and restenosis, acute thrombosis, hyperproliferative cellular response, stents and local drug delivery. They share their expertise on all aspects of the field, including a discussion of results from preclinical and clinical studies, and they examine alternative methods of molecular delivery to the vessel wall. With coverage of the most current methods and applications, as well as a host of photographs illustrating their implementation, this book will serve as an excellent reference for cardiologists, pharmacologists, cardiac surgeons, and trainees.

Statins: The HMG CoA Reductase Inhibitors in Perspective

Building upon the foundation set in the first edition, Statins: The HMG-CoA Reductase Inhibitors in Perspective examines existing and emerging statins and their beneficial effectiveness in reducing serum cholesterol. The breadth of coverage and depth of information in this book provide an authoritative guide to statins from their discovery through the major clinical trials to the present and explores the future of statin trials and lipid-lowering therapy beyond statins. The book tells the story of statins, for the most part in the words of those who lived it. The major clinical trials from Scandinavia, North America, Australia, New Zealand, and Scotland are detailed by those who conducted them. The book includes information on the pharmacology and mechanisms of action, the statin angiographic trials, the use of statins after vascular surgery, guidelines for the use of the statins in clinical practice, and the cost-effectiveness of statin therapy. New chapters cover combination therapy in lipid-lowering, new 'Megatrials' (HPS and PPP), and the PROSPER study.

USMLE Pharmacology and Treatment Flashcards

USMLE Pharmacology and Treatment Flashcards: The 200 Questions You're Most Likely to See on the Exam For Steps 1, 2&3

Description: • Color flashcards in laminated 7 x 5 format• Cards indexed and categorized by medical field, with full-color labeling• Questions on one side, with answers on the back• Treatments (what you should prescribe for your patient) you are most likely to see on the USMLE Step 1, 2, and 3 exam• An online podcast with additional test-taking tips from test expert Conrad Fischer

Download: Ziddu


۱۳۸۷ بهمن ۵, شنبه

How to Read a Paper

این کتاب نحوه استفاده و خواندن مقالات را برای متخصصین و محققین علوم زیستی و پزشکی به صورت بسیار مفید توضیح می دهد. این کتاب از انتشارات British Medical Journal می باشد.

The Cannabinoid Receptors

As research has progressed, the cannabinoid CB 1 and CB 2 receptors have expanded significantly in importance within the neuroscience mainstream. In The Cannabinoid Receptors, leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid system, and ultimately, the whole animal pharmacology and therapeutic applications for cannabinoid drugs. Adding to those key topics, the book also examines the current direction of the field with chapters on new putative cannabinoid receptors and challenges for future research. As a part of The Receptors ™ series, this volume highlights its receptor with the most thorough, focused and essential information available.Comprehensive and cutting-edge, The Cannabinoid Receptors serves as an ideal guidebook to what continues to be a fascinating and vital field.

۱۳۸۷ دی ۳۰, دوشنبه

Clinician's Pocket Reference, 11th Edition

The original Scut Monkey Handbook is the market-leading survival guide for the wards and in the clinic! This portable, pocket-sized "manual of manuals" provides essential patient care information for medical students. You will find totally up-to-date coverage of current treatment protocols and step-by-step information on the history and physical examination, differential diagnosis, key lab and diagnostic tests, and much more.
Revised format and design delivers bulleted, concise information as well as numerous flow charts and tables Thoroughly updated and revised with particular attention on topics such as clinical microbiology, critical care, emergencies, and commonly used medications.

Pharmacotherapy Handbook, 7 Ed

Essential Pharmacotherapy Data at Your Fingertips! Pharmacotherapy Handbook delivers the essential information you need to quickly and confidently make drug therapy decisions for eighty-four diseases and disorders. Featuring a convenient alphabetized presentation, the book utilizes text, tables, figures, and treatment algorithms to make important drug data readily accessible and easily understandable. Features: Consistent chapter organization that includes:. Disease state definition,. Concise review of relevant pathophysiology,. Clinical presentation,. Diagnosis,. Desired outcome,. Treatment,. Monitoring Six valuable appendices, including a new one on the management of pharmacotherapy in the elderly. NEW chapters on adrenal gland disorders and influenza. The ideal companion Pharmacology: A Pathophysiologic Approach, 7e by Joseph DiPiro et al.

Veterinary Psychopharmacology

Every day veterinarians in practice are asked to treat pets exhibiting problem behaviors. In the last several years pharmacologic treatments of behavior have made significant advances and can serve as a critical part of therapy.Veterinary Pscyhopharmacology is a complete source of current knowledge on the subject of pharmacologic behavior modification that veterinarians can turn to for the answers they need.Classification of disorders is eschewed in favor of in-depth explanations of pharmacologic options in inducing behavior changes. Special emphasis is given to explaining the underlying mechanism of pharmacologic agents used in therapy; thus, veterinarians will know not only which drugs to prescribe but why they should be prescribed and how they work.Veterinary behaviorists, their students and residents, veterinary practitioners of all levels, and veterinary students will find this book invaluable in providing information about their patients' behavior problems and the psychoactive medications that might help them.

۱۳۸۷ دی ۲۵, چهارشنبه

اصول کلی فلوسیتومتری

Flow cytometry is a technology that allows a single cell to be measured for a variety of characteristics, determined by looking at how they flow in liquid [1]. Instruments used for this can gather information about cells by measuring visible and fluorescent light emissions, allowing cell sorting based on physical, biochemical and antigenic traits.
Flash Animations of Flow Cytometry:
Flow Cytometry Principles

Flow Cytometry Animation 1

"Poisoning And Drug Overdose"

کتاب مسمومیت های دارویی.

The manual on the diagnosis and treatment of poisoning and drug overdose, written by the staff and faculty of the California Poison Control System, one of the country’s most respected poison control systems.

The Fifth Edition features:
# Critical insights into timely topics such as biological warfare agents and the newest antidotes.
# Updated information on industrial chemicals, including the most recent regulatory exposure limits.
# Expanded information, including special pregnancy considerations.
# Easy-to-read text and tables containing specific drug dosage information.
# Detailed table summarizing current toxicity and workplace exposure guidelines for more than 500 industrial chemicals.
# Extensive cross-referencing.
# Comprehensive index featuring generic, chemical, and brand names for many drugs and commercial products.

This is an excellent resource for poison control centers, toxicologists, and healthcare practitioners for the diagnosis, treatment, and management of poisonings as a result of exposure to a wide variety of industrial, therapeutic, illicit, and environmental chemicals. 4 Stars!"--Doody's Review Service.

With each bestselling edition, Poisoning And Drug Overdose has helped poison control staff, medical toxicologists, and emergency physicians respond to drug-related emergencies and chemical exposures. The new edition of this exceptional, at-a-glance guide offers the latest advice needed for the effective diagnosis and treatment of poisoning and drug overdose.

Download RapidShare

۱۳۸۷ دی ۱۶, دوشنبه

Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th Edition

The undisputed leader in medical pharmacology, without equal. Updated to reflect all critical new developments in drug action and drug-disease interaction. This is the “desert island” book of all medical pharmacology—if you can own just one pharmacology book, this is it.


Download part1

Download part2

Download part3

کنترل مقدار و زمان آزاد شدن دارو در بدن با نانوتکنولوژی

محققان آمریکایی می گویند توانسته اند قدرت ذرات طلا در ابعاد نانو را مهار کنند و با آن روشی بهتر برای انتقال دارو به محل تحت درمان در بدن انسان ارائه دهند.
ذرات طلا در ابعاد نانو که اشکال متفاوت دارند، قادرند داروهای مختلف را در داخل بدن حمل کنند.
گروه محققان انستیتو تکنولوژی ماساچوست (MIT)، نتیجه تحقیقات خود را در نشریه "ای سی ان نانو" چاپ کرده و در این گزارش همچنین آورده است که با استفاده از این روش جدید داروها فقط در نقطه ای از بدن فعال می شوند که به نوعی بیماری (مثلا سرطان)، مبتلا شده است؛ با این روش همچنین می توان مقدار دارویی را که جذب بدن می شود، تحت کنترل داشت.
روش جدید بر این اساس پایه گذاری شده که هر ذره مختلف از طلا (در ابعاد نانو)، در سطح متفاوتی از نور مادون قرمز ذوب می شود و به همین دلیل داروهای متفاوت را می توان با ذرات متفاوت طلا در بدن آزاد کرد.
یکی از مزایای انتقال مستقیم دارو به نقطه ای خاص از بدن این است که پزشکان می توانند داروهایی که نسبتا مسمویت زا هستند را بدون واهمه از آسیب رساندن به سلول های سالم به محل تمرکز بیماری منتقل کنند.
در شماری از آزمایش ها نشان داده شده است که می توان از ذرات در ابعاد نانو، که گاه به کوچکی یک نانو متر یا یک میلیاردم متر است، برای انتقال مستقیم دارو به محل تومور استفاده و از عوارض جانبی که شیمی درمانی معمولا به همراه دارد، اجتناب کرد.
نور نزدیک به مادون قرمز به بدن تابیده می شود که پس از نفوذ از پوست به محل تومور می رسد. حرارت این نور وقتی به حد نصاب برسد ذرات طلا آب و دارو آزاد می شود.
انتقال دارو در نوبت های مختلف
اما بیماری هایی مانند سرطان و اچ آی وی/ایدز معمولا به درمان های پیچیده نیاز دارند و داروها باید در نوبت های متفاوت به بیمار داده شود.
وسیله ای که توسط محققان ام آی تی ساخته شده است شامل دو ذره نانو به اشکال مختلف است که نقطه ذوب مختلف دارند و می توانند داروها را به طور کنترل شده در بدن آزاد کنند.
اندی ویجایا، از محققان این گروه می گوید: "ما فقط با کنترل کردن امواج نور مادون قرمز می توانیم زمان آزاد شدن مواد دارویی در بدن بیمار را تنظیم کنیم."
این وسیله به طور نظری می تواند با ایجاد ذرات با اشکال مختلف تا چهار داروی مختلف را حمل کند.
کت آرنی، از بنیاد مطالعات سرطان بریتانیا، می گوید که "ذرات نانو در تحقیقات درباره سرطان موضوعی بسیار جالب توجه بوده چون این ذرات می توانند مستقیما تومورها را هدف قرار دهند و شمار زیادی از داروها را به این موضع از بدن منتقل کنند."
خانم آرنی افزود: "روش جدید خیلی هوشمندانه است چون به این معنی است که شمار متفاوتی از داروهای متفاوت را در بدن آزاد می کند. اما این تحقیق با این که مهیج است هنوز در مراحل اولیه خود قرار دارد و هنوز برای درمان بیماران قابل استفاده نیست."

۱۳۸۷ دی ۱۴, شنبه

Stockley's Drug Interactions, 8th Edition

کتاب تداخلات دارویی استاکلی رفرانس خوبی در این زمینه است.

First published over twenty years ago, "Stockley's Drug Interactions" is still the most indispensable and authoritative international source of drug interaction information. Based upon the many thousands of published clinical papers and reports, it provides a series of detailed yet concise monographs designed for quick and easy reference. Each monograph contains a summary, clinical evidence for the interaction under discussion, its probable mechanism, clinical importance and management. Individual interactions are assembled alphabetically into chapters, grouped therapeutically, pharmacologically or individually. Both Recommended International Nonproprietary Names (rINN) and US Adopted Names (USAN) are used throughout the book.

Download Depositfiles

۱۳۸۷ دی ۱۳, جمعه

Encyclopedia of Molecular Pharmacology

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Download Rapidshare